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Procedure

Esophagectomy Esophagogastrectomy Endoscopic resection Other Not specified

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Tumor Site A word about tumor location

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A word about tumor location

This protocol DOES NOT apply to:

• 1) Carcinomas involving the EGJ, with tumor midpoint >2 cm into the proximal stomach (use CAP protocol for gastric cancer)
• 2) Carcinomas of the cardia/proximal stomach without involvement of the EGJ even if tumor midpoint is ≤2 cm into the proximal stomach (use CAP protocol for gastric cancer)
• 3) Lymphomas, gastrointestinal stromal tumors, and sarcomas.

Cervical (proximal) esophagus Mid esophagus, upper thoracic esophagus Mid esophagus, middle thoracic esophagus Mid esophagus, not otherwise specified Distal esophagus (low thoracic esophagus) Esophagogastric junction (EGJ) Proximal stomach/cardia Other Esophagus, not otherwise specified

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Relationship of Tumor to Esophagogastric Junction

Tumor is entirely located within the tubular esophagus and does not involve the GEJ Tumor midpoint lies in the distal esophagus and tumor involves GEJ Tumor midpoint is located at GEJ Tumor midpoint is 2 cm or less into the proximal stomach and tumor involves the GEJ Not specified Cannot be assessed

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Tumor Size (cm)

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Histologic Type

Adenocarcinoma Adenoid cystic carcinoma Mucoepidermoid carcinoma Adenosquamous carcinoma Squamous cell carcinoma Basaloid squamous cell carcinoma Spindle cell squamous cell carcinoma Verrucous squamous cell carcinoma Undifferentiated carcinoma Lymphoepithelioma-like carcinoma Large cell neuroendocrine carcinoma Small cell neuroendocrine carcinoma Neuroendocrine carcinoma (poorly differentiated)# Mixed squamous cell carcinoma-neuroendocrine carcinoma Mixed adenocarcinoma-neuroendocrine carcinoma Mixed adenocarcinoma-neuroendocrine tumor G1: Well-differentiated neuroendocrine tumor G2: Well-differentiated neuroendocrine tumor G3: Well-differentiated neuroendocrine tumor Other histologic Carcinoma, type cannot be determined

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Histologic Grade

G1: Well differentiated G2: Moderately differentiated G3: Poorly differentiated, undifferentiated GX: Cannot be assessed Not applicable

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Tumor Extension

No evidence of primary tumor High-grade dysplasia/carcinoma in situ Tumor invades the lamina propria Tumor invades the muscularis mucosae Tumor invades the submucosa Tumor invades the muscularis propria Tumor invades adventitia Tumor invades adjacent structures Cannot be assessed

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Margins

All margins are uninvolved by invasive carcinoma, dysplasia, and intestinal metaplasia At least one margin involved by neoplasm

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Treatment Effect A word about scoring treatment effect

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A word about scoring treatment effect

No known presurgical therapy Present (complete response, score 0) Present (near complete response, score 1) Present (partial response, score 2) Absent (poor or no response, score 3) Cannot be determined

using the modified Ryan scoring system

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Lymphovascular Invasion

Not identified Present Cannot be determined

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+ Perineural Invasion

Not identified Present Cannot be determined

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Regional Lymph Nodes

Check here if any lymph nodes submitted?

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Pathologic Staging (pTNM)

TNM Descriptors (select all that apply)

Not applicable m r y

pT

pTX: Tumor cannot be assessed pT0: No evidence of primary tumor pTis: High-grade dysplasia, defined as malignant cells confined to the epithelium by pT1a: Tumor invades the lamina propria or muscularis mucosae pT1b: Tumor invades the submucosa pT2: Tumor invades the muscularis propria pT3: Tumor invades adventitia pT4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum pT4b: Tumor invades other adjacent structures, such as aorta, vertebral body, or airway

pN

pNX: Regional lymph nodes cannot be assessed pN0: No regional lymph node metastasis pN1: Metastasis in one or two regional lymph nodes pN2: Metastasis in three to six regional lymph nodes pN3: Metastasis in seven or more regional lymph nodes

pM

pMx: Not applicable pM1: Distant metastasis

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+ Additional Pathologic Findings (select all that apply

None identified Intestinal metaplasia (Barrett’s esophagus) Low-grade squamous dysplasia High-grade squamous dysplasia Low-grade glandular dysplasia High-grade glandular dysplasia Esophagitis (type Gastritis (type) Other