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A word about this updated CNS tumor map

In the spring of 2020, I decided to once again go through the latest revision to the WHO CNS tumor book, and re-do this CNS tumor map. While previously, the differential diagnoses were strongly influenced by age and location, it is clear that molecular genetics may trump these pre-test metrics. I have tried to include the relevant molecular genetic features in the map.

It's important to consider how many new entities are being defined, in this era of high-throughput tumor sequencing and methylation based tumor classification schemes. Novel tumors with similar histologic and immunophenotypic profiles are separated using biologic characteristics that are only accessible with ancillary studies. Nevertheless, there are nearly 50 distinct tumors incorporated in this map that you may encounter in routine practice.

Lastly, given the need to be able to read the text within these small boxes, I would highly recommend you print this as a multipage poster. This can be done using free adobe reader software, under print > poster > 50% tile scale. The document is mor readable. I have posted several versions of the map to suit your preference, including a "large font" version that you can print on a single page and still (with some effort) read.

- Chandra

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