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Procedure
Tumor Site
Tumor Size (cm)
Tumor Focality
Histologic Type and Grade
Mitotic Rate
A word about the mitotic rate
Mitotic rate should be reported as number of mitoses per 2 mm2, by evaluating at least 10 mm2 in
the most mitotically active part of the tumor. Only clearly identifiable mitotic figures should be
counted; hyperchromatic, karyorrhectic, or apoptotic nuclei are excluded. Because of variations in
field size, the number of high-power fields (HPF) (at 40X magnification) for 10 mm2 (thereby 2 mm2)
must be determined for each microscope (Table 3). For example, if using a microscope with a field
diameter of 0.55 mm, count 42 HPF and divide the resulting number of mitoses by 5 to determine the
number of mitoses per 2 mm2 needed to assign tumor grade.
Mitotic rate should be reported as number of mitoses per 2 mm2, by evaluating at least 10 mm2 in the
most mitotically active part of the tumor (eg, if using a microscope with a field diameter of 0.55 mm,
count 42 high-power fields [10 mm2] and divide
the resulting number of mitoses by 5 to determine the number of mitoses per 2 mm2 needed to assign tumor grade)
