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Procedure

Incisional biopsy Excisional biopsy Partial penectomy Total penectomy Circumcision Other Not specified

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Foreskin

Present (uncircumcised), Short Present (uncircumcised), Medium Present (uncircumcised), Long Present (uncircumcised), Phimotic Not identified (circumcised) Cannot be determined

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Tumor Site

Glans Foreskin mucosal surface Foreskin skin surface Coronal sulcus (balanopreputial sulcus) Skin of the shaft Shaft Penile urethra Penis, NOS

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Tumor Size (cm)

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+ Tumor Focality

Unifocal Multifocal

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+ Tumor Macroscopic Features

Flat Ulcerated Polypoid Verruciform Necrosis Hemorrhage Other

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Histologic Type

Squamous cell carcinoma, usual type Pseudohyperplastic carcinoma Pseudoglandular carcinoma Verrucous carcinoma Carcinoma cuniculatum Papillary squamous cell carcinoma, NOS Adenosquamous carcinoma Sarcomatoid squamous cell carcinoma Basaloid squamous cell carcinoma Papillary-basaloid squamous cell carcinoma Warty carcinoma Warty-basaloid squamous cell carcinoma Clear cell squamous cell carcinoma Lymphoepithelioma-like carcinoma Paget disease Adnexal carcinoma Carcinoma, type cannot be determined Other histologic type

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Histologic Grade

G1: Well differentiated G2: Moderately differentiated G3: Poorly differentiated GX: Cannot be assessed Not applicable

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Tumor Extension (select all that apply)

No evidence of primary tumor Carcinoma in situ Noninvasive localized squamous cell carcinoma Tumor invades lamina propria Tumor invades dermis Tumor invades dartos fascia Tumor invades corpus spongiosum Tumor invades corpus cavernosum Tumor invades tunica albuginea Tumor invades Buck’s fascia Tumor invades penile (distal) urethra Tumor invades regional skin (pubis, inguinal) Tumor invades into adjacent structures Tumor invades other structures Cannot be assessed

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+ Tumor Thickness or Depth of Invasion

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Margins Some definitions of penectomy margins

×

Some definitions of penectomy margins

From the CAP protocol, note G

Cannot be assessed Uninvolved Involved by invasive carcinoma Involved by carcinoma in-situ

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Lymphovascular Invasion

Not identified Present Cannot be determined

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Perineural Invasion

Not identified Present Cannot be determined

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Regional Lymph Nodes

Check here if any lymph nodes submitted?

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Pathologic Staging (pTNM)

TNM Descriptors (select all that apply)

Not applicable m r y

pT

pT0: No evidence of primary tumor pTis: Carcinoma in situ (penile intraepithelial neoplasia [PeIN]) pTa: Noninvasive localized squamous cell carcinoma pT1a: Glans: Tumor invades lamina propria; w/o LVI/PNI and not Grade 3 pT1a: Foreskin: Tumor invades dermis, lamina propria, or dartos fascia; w/o LVI/PNI and not Grade 3 pT1a: Shaft: Tumor invades connective tissue between epidermis and corpora regardless of location; w/o LVI/PNI and not Grade 3 pT1b: Tumor exhibits LVI or PNI or Grade 3 pT2: Tumor invades into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion pT3: Tumor invades into corpora cavernosum (including tunica albuginea) with or without urethral invasion pT4: Tumor invades into adjacent structures (ie, scrotum, prostate, pubic bone)

pN

pNX: Lymph node metastasis cannot be established pN0: No lymph node metastasis pN1: ≤2 unilateral inguinal metastases, no ENE pN2: ≥3 unilateral inguinal metastases or bilateral metastases, no ENE pN3: ENE of lymph node metastases or pelvic lymph node metastases

pM

pMx: Not applicable pM1: Distant metastasis present

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+ Additional Pathologic Findings

HPV-related penile intraepithelial neoplasia (PeIN), warty type HPV-related penile intraepithelial neoplasia (PeIN), basaloid type HPV-related penile intraepithelial neoplasia (PeIN), warty-basaloid type Non-HPV-related PeIN (differentiated [simplex] penile intraepithelial neoplasia) Pleomorphic PeIN Spindle PeIN Clear cell PEIN Pagetoid PEIN Lichen sclerosus Squamous hyperplasia Condyloma acuminatum Other (