Procedure

Specimen Laterality

Tumor Site (macroscopic examination/transillumination)

Tumor Size After Sectioning

Tumor size - Greatest basal diameter (mm)

Tumor size - Greatest thickness (mm)

Tumor Site After Sectioning

Tumor Involvement of Other Ocular Structures Some notes on choroidal invasion

Growth Pattern

Extent of Optic Nerve Invasion

Histologic Grade

+ Anaplasia Grade

+ Cytologic Features Suggesting MYCN Amplification

Margins

Regional Lymph Nodes

Pathologic Staging (pTNM)

TNM Descriptors (select all that apply)

pT

pN

pM

+ Additional Pathologic Findings (select all that apply)

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Some notes on choroidal invasion

An important distinction has been made in the classificaiton of choroidal invasion from the 7th ed to the 8th ed staging manual. See below:

Some examples, from this nice reference: Zoroquiain et al.: Diagnosing Pathological Prognostic Factors in Retinoblastoma: Correlation between Traditional Microscopy and Digital Slides

RB without choroidal invasion. The neoplastic cells are above the retinal pigmented epithelial cells (arrowhead), disrupting them (broad arrow) and pushing Bruch’s membrane but without infiltration (small arrow)