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Procedure

Enucleation Partial exenteration Complete exenteration Other Not specified

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Specimen Laterality

Right Left Not specified

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Tumor Site (macroscopic examination/transillumination)

Cannot be determined Superotemporal quadrant of globe Superonasal quadrant of globe Inferotemporal quadrant of globe Inferonasal quadrant of globe Anterior chamber Between -- and -- o’clock Other

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Tumor Size After Sectioning

Tumor size - Greatest basal diameter (mm)

Tumor size - Greatest thickness (mm)

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Tumor Site After Sectioning

Cannot be determined Superonasal Inferonasal Superotemporal Inferotempora

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Tumor Involvement of Other Ocular Structures Some notes on choroidal invasion

Cannot be determined Cornea Anterior chamber Iris Angle Lens Ciliary body Vitreous Retina Sub-retinal space Sub-retinal pigment epithelial space Optic nerve head Choroid, minimal (solid tumor nest less than 3 mm in maximum diameter [width or thickness]) Choroid, massive (solid tumor nest 3 mm or more in maximum diameter [width or thickness]) Sclera Vortex vein Orbit Other

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Growth Pattern

Cannot be determined Endophytic Exophytic Combined endophytic/exophytic Diffuse Anterior diffuse

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Extent of Optic Nerve Invasion

Cannot be determined None Anterior to lamina cribrosa At lamina cribrosa Posterior to lamina cribrosa but not to end of nerve To cut end of optic nerve

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Histologic Grade

G1: Tumor with areas of retinocytoma (fleurettes or neuronal differentiation) G2: Tumor with many rosettes (Flexner-Wintersteiner or Homer Wright) G3: Tumor with occasional rosettes (Flexner-Wintersteiner or Homer Wright) G4: Tumor with poorly differentiated cells without rosettes and/or with extensive areas (more than half of tumor) of anaplasia GX: Grade cannot be assessed

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+ Anaplasia Grade

Note: Grade based on the highest level of anaplasia in the tumor, with at least 30% of the tumor being able to be graded. Mild Moderate Severe Cannot be determined

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+ Cytologic Features Suggesting MYCN Amplification

Note: Unilateral retinoblastoma with a loose cellular pattern, round nuclei, and prominent multiple nucleoli Absent Present

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Margins

Cannot be assessed No tumor at margins Tumor present at surgical margin of optic nerve Extrascleral extension Other margin(s) involved

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Regional Lymph Nodes

Check here if any lymph nodes submitted?

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Pathologic Staging (pTNM)

TNM Descriptors (select all that apply)

Not applicable m r y

pT

pTX: Unknown evidence of intraocular tumor pT0: No evidence of intraocular tumor pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre- or intralaminar involvement of the optic nerve head pT2: Intraocular tumor(s) with local invasion pT2a: Concomitant focal choroidal invasion and pre- or intralaminar involvement of the optic nerve head pT2b Tumor invasion of stroma of iris and/or trabecular meshwork and/or Schlemm’s canal pT3: Intraocular tumor(s) with significant local invasion pT3a Massive choroidal invasion (>3 mm in largest diameter, or multiple foci of focal choroidal involvement totaling >3 mm, or any full-thickness choroidal involvement) pT3b: Retrolaminar invasion of the optic nerve head, not involving the transected end of the optic nerve pT3c: Any partial-thickness involvement of the sclera within the inner two thirds pT3d: Full-thickness invasion into the outer third of the sclera and/or invasion into or around emissary channels pT4: Evidence of extraocular tumor: tumor at the transected end of the optic nerve, tumor in the meningeal spaces around the optic nerve, full-thickness invasion of the sclera with invasion of the episclera, adjacent adipose tissue, extraocular muscle, bone, conjunctiva, or eyelids

pN

pNX: Regional lymph nodes cannot be assessed pN0: No regional lymph node involvement pN1: Regional lymph node involvement

pM

pMx: Not applicable pM1: Distant metastasis with histopathologic confirmation pM1a: Histopathologic confirmation of tumor at any distant site (eg, bone marrow, liver, or other) pM1b: Histopathologic confirmation of tumor in the cerebrospinal fluid or CNS parenchyma

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+ Additional Pathologic Findings (select all that apply)

None identified Calcifications Apoptosis Mitotic rate Necrosis Basophilic vascular deposits Inflammatory cells Hemorrhage Retinal detachment Neovascularization Other