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Procedure (select all that apply)
Tumor Size (cm)
+ Tumor thickness
There are published and unpublished data from 3 independent prospective cohorts of
Merkel cell carcinoma (MCC) patients examining tumor thickness (measured in millimeters from the stratum granulosum
to the deepest infiltrating tumor cells) as a prognostic indicator for outcome.
Margins - Peripheral
Margins - Deep
+ Tumor-Infiltrating Lymphocytes
+ Tumor Growth Pattern
Pathologic Staging (pTNM)
TNM Descriptors (select all that apply)
Tumor-infiltrating lymphocytes (TILs) are defined as lymphocytes present at the interface of the
tumor and the stroma. Some authors have suggested that the presence of TILs has been shown to portend
a poor prognosis, especially when considered in concurrence with a tumor depth of >5 mm.5 However, there
are conflicting data on the subject.
In the absence of specific accepted guidelines for assessment of TILs, it is recommended in this
protocol that, for purposes of uniformity, pathologists choosing to report TILs employ guidelines
used for assessment of TILs as in cutaneous melanomas, given below: