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Procedure

Excision Partial vaginectomy Radical vaginectomy Other Not specified

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Tumor Site

Vagina, upper third Vagina, middle third Vagina, lower third Vagina, further delineation not specified

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Tumor Size (cm)

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Histologic Type

Squamous cell carcinoma, keratinizing Squamous cell carcinoma, nonkeratinizing Squamous cell carcinoma, basaloid Squamous cell carcinoma, verrucous Squamous cell carcinoma, warty Squamous cell carcinoma, papillary Adenocarcinoma, NOS Mucinous carcinoma, NOS Endometrioid carcinoma Clear cell carcinoma Mesonephric carcinoma Adenosquamous carcinoma Adenoid basal carcinoma Small cell neuroendocrine carcinoma Large cell neuroendocrine carcinoma Undifferentiated carcinoma Carcinosarcoma Other Carcinoma, type cannot be determined

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Histologic Grade

G1: Well differentiated G2: Moderately differentiated G3: Poorly differentiated G4: Undifferentiated GX: Cannot be assessed Not applicable Other

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Other Tissue/ Organ Involvement

Not identified Paravaginal tissues Pelvic sidewall Vagina, lower third Bladder mucosa Rectal mucosa Other organs Cannot be determined

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Margins - Peripheral

Uninvolved by invasive carcinoma Involved by invasive carcinoma Uninvolved by intraepithelial neoplasia Involved by high-grade squamous intraepithelial lesion (VAIN 2-3) Involved by adenocarcinoma in situ (AIS) Cannot be assessed

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Margins - Deep

Uninvolved by invasive carcinoma Involved by invasive carcinoma Uninvolved by intraepithelial neoplasia Involved by high-grade squamous intraepithelial lesion (VAIN 2-3) Involved by adenocarcinoma in situ (AIS) Cannot be assessed

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Lymphovascular Invasion

Not identified Present Cannot be determined

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Regional Lymph Nodes

Check here if any lymph nodes submitted?

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Pathologic Staging (pTNM)

TNM Descriptors (select all that apply)

Not applicable m r y

pT

pT0: No evidence of primary tumor pT1: Tumor confined to the vagina pT1a: Tumor confined to the vagina, measuring ≤2.0 cm pT1b: Tumor confined to the vagina, measuring >2.0 cm pT2: Tumor invading paravaginal tissues but not to pelvic sidewall pT2a: Tumor invading paravaginal tissues but not to pelvic wall, measuring ≤2.0 cm pT2b: Tumor invading paravaginal tissues but not to pelvic wall, measuring >2.0 cm pT3: Tumor extending to the pelvic sidewall# and/or causing hydronephrosis or nonfunctioning kidney pT4: Tumor invading the mucosa of the bladder or rectum and/or extending beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4)

pN

pNX: Regional lymph nodes cannot be assessed pN0: No regional lymph node metastasis pN0(i+): Isolated tumor cells in regional lymph node(s) no greater than 0.2 mm pN1: Pelvic or inguinal lymph node metastasis

pM

pMx: Not applicable pM1: Distant metastasis

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+ FIGO Stage (2015)

I: Carcinoma is limited to the vaginal wall II: Carcinoma has involved the para-vaginal tissue but has not extended to the pelvic wall III: Carcinoma has extended to the pelvic wall and/or involving the lower third of the vagina and/or causing hydronephrosis or nonfunctioning kidney IV: Carcinoma has extended beyond the true pelvis or has involved the mucosa of the bladder or rectum (bullous edema as such does not permit a case to be allotted to stage IV) IVA: Tumor invades bladder and/or rectal mucosa and/or direct extension beyond the true pelvis IVB: Spread to distant organs

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+ Additional Pathologic Findings

Low-grade squamous intraepithelial lesion (VAIN 1) High-grade squamous intraepithelial lesion (VAIN 2-3) Condyloma acuminatum Adenocarcinoma in situ (AIS) Atypical adenosis Other